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ABSTRACT

We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

Subject(s)

Angiotensin II/metabolism , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , Respiratory Distress Syndrome/drug therapy , Shock, Septic/drug therapy , Aged, 80 and over , Angiotensin II/drug effects , Betacoronavirus , COVID-19 , Coronavirus Infections/complications , Coronavirus Infections/metabolism , Humans , Male , Pandemics , Pneumonia, Viral/complications , Pneumonia, Viral/metabolism , Respiratory Distress Syndrome/etiology , SARS-CoV-2 , Shock, Septic/complications , Shock, Septic/metabolism

ABSTRACT

Subject(s)

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